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. Author manuscript; available in PMC: 2013 Apr 19.
Published in final edited form as: Cell Host Microbe. 2012 Apr 19;11(4):364–374. doi: 10.1016/j.chom.2012.02.007

Figure 2. ToxA induces a subset of P. aeruginosa-induced genes through several signaling pathways.

Figure 2

(A) Venn diagrams comparing the overlaps in genes activated by ToxA, Gram-negative P. aeruginosa PA14 (Troemel et al., 2006), and either the yeast C. albicans (Pukkila-Worley et al., 2011) or Gram-positive S. aureus (Irazoqui et al., 2010a). All microarrays were conducted with the Affymetrix GeneChip platform using animals infected at the L4/young adult stage and collected after 24 hours (ToxA), 8 hours (S. aureus), or 4 hours (PA14, C. albicans). See also Figure S2. (B and C) qRT-PCR analysis in different mutant backgrounds of genes normally activated by ToxA. ** Genes with ≥10-fold lower induction to ToxA as compared to wild-type N2 animals with p<0.05. * Genes with ≥5-fold lower induction to ToxA as compared to N2 with p<0.05. Results shown are an average of 6 (N2) or 3 (pmk-1, zip-2, fshr-1) biological replicates. Error bars represent SEM. P values determined with a 2-tailed unpaired t-test.