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. Author manuscript; available in PMC: 2013 Jan 20.
Published in final edited form as: Cell. 2012 Jan 20;148(1-2):59–71. doi: 10.1016/j.cell.2011.12.013

Table 1.

Whole-genome sequencing and DNA sequence variant statistics

LFS-MB1 LFS-MB2 LFS-MB3 LFS-MB4
Tumor bases sequenced 109 × 109 120 × 109 37 × 109 143 × 109
Paired normal tissue bases sequenced 116 × 109 125 × 109 17 × 109 114 × 109
Tumor physical coverage (span coverage) 43.5× 45.8× 77.8× 112.2×
Paired normal physical coverage 41.6× 51.6× 3.3× 49.5×
Tumor sequencing coverage 30.8× 34.6× 8.9×* 38.5×
Paired normal sequencing coverage 31.4× 36.7× 4.6×* 34.4×
Total somatic mutations (whole genome) 3,716 3,053 - 2,494
Non-silent coding mutations (val./tested) 24 (20/21) 22 (19/20) 18(−/−)* 11 (8/10)
Mutation rate per Mb 1.29 1.06 - 0.88
*

In addition to whole-genome sequencing, whole-exome data was generated at 39× (tumor) and 37× (paired normal) coverage in this case.

‘−’, not assessed; val., validated.