FIG. 3.
Echocardiographic changes in aging and mitochondrial mutator mice. Echocardiographic analysis of WT and mCAT C57Bl/6 mice in a longevity cohort (A–D) and Polgm/m in the presence or absence of mCAT `(E–H). (A, E) Left ventricular mass index (LVMI=calculated LVM/body weight), (B, F) systolic function measured by percentage of fractional shortening (FS), (C, G) diastolic function measured by tissue Doppler imaging Ea/Aa, (D, H) the myocardial performance index (MPI) were analyzed. The linear trends across ages in WT mice were significant for all parameters (p<0.05 for all, left panels). The beneficial effect of mCAT versus WT was analyzed by the interaction between genotype and the linear age trend, and was significant in all cases (p<0.01 for all except fractional shortening, p=0.03). *p<0.05 versus Polgm/m at 4–6 months old, #p<0.05 versus Polgm/m at 13–14 months old (right panels). Data reanalyzed from Dai, et al. (67,71). LVMI, Left ventricular mass index; mCAT, catalase targeted to mitochondria.