Figure 5.
Relationship of white matter disruption and amyloid deposition. WMH volume and amyloid burden (PiB DVR) were measured in individual participants and used to classify individuals into high (WMH+) and low (WHM−) WMH groups and high (PiB+) and low (PiB−) amyloid groups. While many individuals had one or the other of these pathologies, only 4 individuals were classified as being high on both measures, suggesting that these pathologies have distinct etiologies. There was no correlation between the 2 measures of pathology, r = 0.02, P = 0.88.
