Figure 1. Exome Sequencing in Nine Patients with Low-Grade Myelodysplastic Syndromes (MDS).
Panel A shows the distribution of numbers and categories of somatically acquired point mutations among the nine patients. No mutations were found for Patient 5. Panel B shows the mutation spectrum for somatically acquired point mutations. Panel C shows the fraction of reads reporting mutated alleles from exome-sequencing data for each patient. No mutations were found for Patient 5. Mutations in known MDS genes or recurrently mutated genes identified in this screen are shown as colored points, with nonrecurrent mutations as gray points. P values were calculated with the use of chi-square tests of heterogeneity in observed allelic ratios for mutations in patients with more than two mutations.