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. Author manuscript; available in PMC: 2012 Oct 5.
Published in final edited form as: Nature. 2012 Mar 18;484(7392):105–109. doi: 10.1038/nature10907

Figure 1. Wild type bone marrow transplantation at P28 arrests disease progression in Mecp2−/y mice.

Figure 1

a, Representative images of wild type and Mecp2−/y littermates at P56. b, Lifespan of Mecp2−/y mice receiving wild type bone marrow at P28 (Wild type→Mecp2−/y; n = 15) is compared to naïve Mecp2−/y (n = 17), Mecp2−/y receiving Mecp2−/y bone marrow (Mecp2−/y→Mecp2−/y; n = 9), and wild type mice receiving wild type bone marrow (Wild type→Wild type; n = 29) (***, p < 0.0001, Log Rank (Mantel-Cox)). c, Representative images of Wild type→Wild type as compared to Wild type→Mecp2−/y are shown at P56 (4 weeks post bone marrow transplantation). d, Weights (mean ± s.e.m.) of Wild type→Wild type, Mecp2−/y, Mecp2−/y→Mecp2−/y and Wild type→Mecp2−/y mice (n = 15, 15, 7, 15 mice/group) are shown over time. e, Representative images of brains isolated from P56 Wild type→Wild type and Wild type→Mecp2−/y mice transplanted at P28 and naïve Mecp2−/y mice are presented; f, Brain weight (mean ± s.e.m.) per each group (***, p < 0.001; one-way ANOVA; n = 4 each group). g, Representative images of Nissl staining in hippocampal slices (CA1 area) of wild type and Mecp2−/y mice are presented (bar equals 40 μm). h, Soma area (mean ± s.d.) of CA1 hippocampal cells. For each group of mice, a set of cells was created by randomly selecting 100 cells per mouse, 3 mice per group (***, p < 0.001; Two-way ANOVA with Bonferroni post-hoc test).