Table 3.
Risk of death from breast cancer in high staining intensity groups compared to low staining intensity groups
| Log Rank test | Unadjusted HR (95% CI) | Multivariate adjusted* HR (95% CI) | ||
|---|---|---|---|---|
| COX-2 | TP | P = 0.322 | 0.6 (0.2-1.7), P = 0.339 | 0.6 (0.2-2.2), P = 0.485 |
| SP | P = 0.020 | 3.9 (1.1-14.2), P = 0.036 | 3.5 (0.8-14.7), P = 0.059 | |
| TM | P = 0.074 | 2.3 (0.8-6.9), P = 0.121 | 1.5 (0.4-6.0), P = 0.592 | |
| SM | P = 0.003 | 6.8 (1.5-30.4), P = 0.013 | 8.3 (4.2-27.7), P 0.024 | |
| TGF-β | TP | P = 0.984 | 1.0 (0.3-2.8), P = 0.989 | 2.2 (0.6-8.8), P = 0.249 |
| SP | P = 0.839 | 1.1 (0.4-3.3), P = 0.842 | 5.2 (1.1-24.0), P = 0.035 | |
| TM | P = 0.052 | 0.4 (0.1-4.1), P = 0.069 | 1.4 (0.3-6.6), P = 0.701 | |
| SM | P = 0.032 | 3.0 (1.0-9.2), P = 0.046 | 2.3 (0.7-8.0), P = 0.174 | |
| IL-10 | TP | P = 0.130 | 2.2 (0.8-6.4), P = 0.149 | 5.2 (1.3-20.6), P = 0.018 |
| SP | P = 0.384 | 1.7 (0.5-5.3), P = 0.400 | 1.1 (1.0-1.8), P = 0.003 | |
| TM | P = 0.009 | 5.7 (1.3-25.6), P = 0.023 | 4.7 (0.8-25.5), P = 0.076 | |
| SM | P = 0.035 | 4.4 (1.0-19.7), P = 0.053 | 4.0 (0.8-20.7), P = 0.057 | |
| Ki67 | TP | P = 0.257 | 1.8 (0.6-5.3), P = 0.275 | 1.2 (0.3-4.7), P = 0.771 |
| SP | P = 0.369 | 1.7 (0.5-6.1), P = 0.387 | 1.1 (0.2-6.5), P = 0.959 | |
| TM | P = 0.001 | 7.7 (1.7-35.2), P = 0.008 | 7.4 (1.4-33.3), P = 0.020 | |
| SM | P < 0.000 | 3.6 (1.0-12.9), P = 0.031 | 1.1 (1.0-1.8), P = 0.002 | |
*Adjusted for age, histology (grade 1, 2 and 3, tumor size, oestrogen- and progesterone receptor positivity (yes/no).
Abbreviations: TP: tumor cell areas of primary tumors; SP: tumor stromal areas of primary tumors; TM: tumor cell areas of metastases; SM: tumor stromal areas of metastases