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Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) injection reduced the Klotho expression in renal tubules. (a) Real-time PCR and (b) western blotting revealed that Klotho mRNA and protein expression were significantly lower in kidneys treated with IS or PCS. (c) Immunofluorescence staining indicated that the intensity of positive Klotho staining in renal tubules was significantly decreased in mice treated with IS or PCS. *P<0.05 vs. control.
