FIG. 4.
CD1−/− mice have reduced lesion size following traumatic brain injury (TBI). (A) Unbiased stereological assessment of lesion volume at 21 days post-TBI was performed on cresyl violet-stained brain sections. The stained brain sections from CD1−/− animals revealed sparing of hippocampal tissues. (B) Lesion quantification. CD1−/− mice had reduced (*p=0.004 versus CD1+/+ mice) lesion size at 21 days. Analysis by one-tailed paired Student's t-test was done (mean±standard error of the mean (SEM); n=5–6/group). (C) T2-weighted magnetic resonance imaging (MRI) analysis was performed on a subset of animals at 21 days. (D) Lesion quantification. CD1−/− mice had decreased (*p=0.003 versus CD1+/+ mice) lesion size at 21 days. Analysis by one-tailed paired Student's t-test (mean±SEM; n=3–4/group). (E) Linear regression analysis comparing TBI-induced lesion size as quantified by histology and MRI analysis at 21 days post-TBI (p<0.0001 by Pearson's correlation; r2=0.91).