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Activity of ACPT-1 and LSP1-2111 on mGlu receptors
| EC50 (μm) | ||
|---|---|---|
| ACPT-I | LSP1-2111 | |
| Group I | – | NE |
| Group II | – | NE |
| Group III | ||
| mGlu4 | 1.7 ± 0.23 | 2.2 ± 0.27 |
| mGlu6 | 10.60 ± 3.38 | 1.7 ± 0.13 |
| mGlu7 | 280.5 ± 84.5 | 52.87 ± 20.66 |
| mGlu8 | 5.13 ± 0.84 | 65.97 ± 11.81 |
EC50 values are means ± SEM
NE compound has no agonist or antagonist activity at 100 μm (Beurrier et al. 2010)
