FIG. 1.
Neogenesis in mouse pancreas. A: The metaplastic ducts seen in the zinc-treated metallothionen. TGF-α transgenic mice have 6% insulin+ (red, white arrows) cells and some amylase+ (green, yellow arrow) cells. Tissue from study reported in (37); the background in the red channel was enhanced to see the context of the ducts. Magnification bar = 100 μm. B: After partial (70–80%) pancreatectomy in adult mice, insulin+ (blue) cells “budding” from proliferating ductules labeled with E-cadherin (red) are found in well-defined areas termed foci of regeneration that further differentiate into new lobes of pancreas (40). Magnification bar = 50 μm. (A high-quality digital representation of this figure is available in the online issue.)