Figure 3.
dp53 and JNK are able to activate each other independently of dronc function. (a and b) In sal>dp53 (spaltEPv-Gal4>UAS-dp53 UAS-GFP; puc-lacZ/+) and sal>dp53 dronc− (spaltEPv-Gal4>UAS-dp53 UAS-GFP; pucE69-lacZ dronc124/dronc129) discs, the JNK pathway becomes activated, as revealed by the puc-LacZ marker. In otherwise wild-type discs, puc-lacZ expression is restricted to the most proximal cells (inset). Conversely, driving JNK expression in the sal domain activates dp53 transcription in both dronc+ and dronc− discs (c and d)