Table 1.
Components of SWI/SNF are mutated in pancreatic cancer
| Gene name (transcript accession identification) | Tumor/cell line | Amino acid | Mutation type | Source | Frequency |
| ARID1A (CCDS285.1) | A32-1 | p.R1276X | Nonsense | Jones et al. (8) | 8% (2 of 25) |
| 185 | fs | INDEL | |||
| Hs766T | p.Q538X | Nonsense | RNAseq | ||
| Panc1 | In-frame | Rearrangement | |||
| PBRM1 (CCDS2859.1) | PL45 | p.R502X | Nonsense (homozygous) | Jones et al. (8) | 8% (2 of 25) |
| 140 | p.P1269L | Missense | |||
| SMARCA4 (CCDS12253.1) | A10.7 | p.Q1196X | Nonsense (homozygous) | Jones et al. (8) | 8% (2 of 25) |
| TS 0111 | Splice site | Splice site | |||
| Hs700T | fs | Frameshift (homozygous) | Wong et al. (21) | 18% (2 of 11) | |
| SU86.86 | p.Q160R | Missense | |||
| Panc1 | fs | Rearrangement | RNAseq |