Figure 3.
Uncertainty vs βmax for the yeast polarization model. All data were generated using the same simulation settings as in Fig. 2, except for the value of κmin. Panel (a) was generated with κmin = 10, and panel (b) was generated with κmin = 30. Estimated uncertainties obtained with κmin = 10 display significantly higher variability among the four ensembles than the estimates obtained with κmin = 20 or κmin = 30. As the magnitude of the rare event probability is very small, we suspect that greater numbers of firings are required in each bin to obtain reliable estimates of the state-dependent IS parameters.