Table 3.
Performance of multivariable logistic regression models for clinical and microbiological responses
| Model description | Variable 1 | Variable 2a | No. of patients with successful response | Total no. of patients | Proportion with successful response | Avg model-estimated probability of successful response |
|---|---|---|---|---|---|---|
| Model 1 for clinical response | AUC0-24:MIC ratio, <0.9 | Albumin, <2.6 g/dl | 1 | 7 | 0.14 | 0.21 |
| AUC0-24:MIC ratio, <0.9 | Albumin, ≥2.6 g/dl | 3 | 4 | 0.75 | 0.64 | |
| AUC0-24:MIC ratio, ≥0.9 | Albumin, <2.6 g/dl | 12 | 21 | 0.57 | 0.57 | |
| AUC0-24:MIC ratio, ≥0.9 | Albumin, ≥2.6 g/dl | 27 | 29 | 0.93 | 0.93 | |
| Model 2 for microbiological response | Non-VAP | Albumin, <2.6 g/dl | 9 | 13 | 0.69 | 0.67 |
| Non-VAP | Albumin, ≥2.6 g/dl | 24 | 25 | 0.96 | 0.97 | |
| VAP | Albumin, <2.6 g/dl | 4 | 15 | 0.27 | 0.30 | |
| VAP | Albumin, ≥2.6 g/dl | 7 | 8 | 0.88 | 0.82 | |
| Model 3 for microbiological response | MIC, <0.5 mg/liter | Albumin, <2.6 g/dl | 6 | 12 | 0.50 | 0.45 |
| MIC, <0.5 mg/liter | Albumin, ≥2.6 g/dl | 18 | 20 | 0.90 | 0.93 | |
| MIC, 0.5 or 1.0 mg/liter | Albumin, <2.6 g/dl | 6 | 9 | 0.67 | 0.68 | |
| MIC, 0.5 or 1.0 mg/liter | Albumin, ≥2.6 g/dl | 9 | 9 | 1.0 | 0.99 | |
| MIC, >1.0 mg/liter | Albumin, <2.6 g/dl | 1 | 7 | 0.14 | 0.25 | |
| MIC, >1.0 mg/liter | Albumin ≥2.6 | 4 | 4 | 1.0 | 0.82 |
a
Albumin was evaluated as a two-group variable for descriptive purposes. Final models (described in Table 2) were based on the continuous form of this variable.