Figure 4.
(A) Schematic diagram of the NPCP-Cy5.5-CTX nanoprobes. In vivo MR images of ND2:SmoA1 (B) and wild-type mice (C) acquired before and 48 h after administration of either NPCP-CTX or the NPCP nanoprobes. Colorized R2 maps of the brain region were superimposed onto the proton density-weighted images. (D-E) In vivo near-IR fluorescence images of autochthonous medulloblastoma tumors in ND2:SmoA1 mice injected with NPCP-Cy5.5-CTX or NPCP-Cy5.5, alongside those receiving no injection: 2 h post-injection (D) and 120 h post-injection (E). Ex vivo fluorescence images of mice brains from the same mice following necropsy (inset). The spectral gradient bar corresponds to the fluorescence intensity (p/s/cm2/sr) in the images. Reproduced with permission from ref. 73.