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Three of the six Mpk1-activating mutations identified in the genetic screen are conserved in human Erks. The sequence alignment of the yeast Mpk1 and the mammalian Erk1 and Erk2 MAPKs is shown. Conserved mutation sites are shown in rectangles. Non-conserved mutation sites are shown in circles. Thr-123 of Mpk1 (Ser-139 in Erk1 and Ser-120 of Erk2) is marked by an asterisk.
