Fig. 3.
Trimetazidine and ranolazine improve RV GO and ATP production and reduce plasma lactate levels in PAB. a, c In RV whole tissue samples, O2 consumption is depressed in RVH, and this is restored by long-term treatment with either pFOXi. These measurements were made with glucose as the only substrate and thus reflect GO. b, d Although RVATP levels are not significantly reduced in RVH vs sham, both pFOXi increase RV ATP levels. e After 30 min of exercise, serum lactate levels increase in PAB rats. Long-term treatment with either pFOXi reduces exertional lactic acidemia