Fig. 1.

Steps in the apoptotic cell clearance process. Find-me signals (such as nucleotides) recruit motile phagocytes to the site of death. Exposure of eat-me signals (such as PtdSer) on the apoptotic cell allow for binding/recognition by the engulfment receptors (such as BAI1, TIM-4) on the phagocyte. The recognition is followed by phagocytosis/internalization of the apoptotic cell. The degradation of the apoptotic cell and managing the ingested cellular components then follow.