Figure 5.
The change in plasma triglyceride levels in response to fasting is dependent on the FXR genotype. (A,B) Fasting decreases plasma triglyceride levels. Male (A) and female (B) FXR+/+ or FXR-/- mice (n = 4 or 5 per group) were either fed a chow diet or fasted for 24 h. Blood samples were collected and plasma triglyceride levels (mean ± SE) were determined. (C,D) Fasting increases total plasma cholesterol and plasma free fatty acids. Plasma total cholesterol (C) or free fatty acids (D; mean ± SE) are shown for the same mice. (*) p < 0.05; (**) p < 0.01.