Table 3. Differential gene expression of metastasis-related genes upon miR-215 overexpression in kidney cancer cell lines.
| Cell process | Unigene | Symbol | Description | Fold regulation |
|---|---|---|---|---|
| Cell adhesion | Hs.461086 | CDH1 | Cadherin 1, type 1, E-cadherin (epithelial) | −1.549 |
| Hs.116471 | CDH11 | Cadherin 11, type 2, OB-cadherin (osteoblast) | 1.522 | |
| Hs.171054 | CDH6 | Cadherin 6, type 2, K-cadherin (fetal kidney) | 2.633 | |
| Hs.524484 | ITGA7 | Integrin, α7 | −1.467 | |
| Hs.449909 | RPSA | Ribosomal protein SA | −1.503 | |
| Hs.534797 | CTNNA1 | Catenin (cadherin-associated protein), α1, 102kDa | 1.200 | |
| Extracellular matrix | Hs.2936 | MMP13 | Matrix metallopeptidase 13 (collagenase 3) | 1.270 |
| Hs.375129 | MMP3 | Matrix metallopeptidase 3 (stromelysin 1, progelatinase) | −1.394 | |
| Hs.2256 | MMP7 | Matrix metallopeptidase 7 (matrilysin, uterine) | 1.461 | |
| Hs.644633 | TIMP3 | TIMP metallopeptidase inhibitor 3 | 1.379 | |
| Hs.44227 | HPSE | Heparanase | −1.251 | |
| Cell-cycle regulation | Hs.202453 | MYC | V-myc myelocytomatosis viral oncogene homolog (avian) | −1.200 |
| Cell proliferation | Hs.160562 | IGF1 | Insulin-like growth factor (somatomedin C) | −1.484 |
| Hs.251526 | CCL7 | Chemokine (C-C motif) ligand 7 | −1.598 | |
| Hs.478275 | TNFSF10 | Tumour necrosis factor (ligand) superfamily, member 10 | 2.126 | |
| Hs.523329 | EPHB2 | EPH receptor B2 | −1.043 | |
| Hs.279522 | NR4A3 | Nuclear receptor subfamily 4, group A, member 3 | −1.257 | |
| Hs.494178 | RORB | RAR-related orphan receptor B | 1.573 | |
| Hs.514451 | SSTR2 | Somatostatin receptor 2 | −1.377 | |
| Hs.160411 | TSHR | Thyroid-stimulating hormone receptor | 1.370 | |
| Hs.155942 | TRPM1 | Transient receptor potential cation channel, subfamily M, member 1 | 1.252 | |
| Hs.208229 | KISSR1 | KISS1 receptor | −1.192 | |
| Hs. 165950 | FGFR4 | Fibroblast growth factor receptor 4 | −1.197 | |
| Transcription factor | Hs.12253 | SMAD2 | SMAD family member 2 | −1.232 |
| Other genes | Hs. 143212 | CST7 | Cystatin F (leukocystatin) | −1.195 |
| related to | Hs.632466 | CTSK | Cathepsin K | 1.224 |
| metastasis | Hs.95008 | KISS1 | KISS-1 metastasis-suppressor | 1.206 |
| Hs.444986 | METAP2 | Methionyl aminopeptidase 2 | −1.387 |
Abbreviation: miRNA=microRNA.