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Schematic of the longest human tau isoform and the other major tau isoforms found in humans that are generated through posttranscriptional splicing of exons 2 (I1), 3 (I2), and 10 (R2). The inclusion or exclusion of exon 10 results in tau with four or three binding repeats within the MT binding domain (4R-tau or 3R-tau), respectively. Amino acid numbers are depicted along the bottom of the longest tau isoform.
