Skip to main content
. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Neurobiol Aging. 2011 Dec;32(Suppl 1):S20–S36. doi: 10.1016/j.neurobiolaging.2011.09.006

Table 1.

Pathological Correlation of In Vivo PiB Retention

Clinical
Diagnosis		 PiB
Status		 Scan-PM
Intervala 		Autopsy Aβ ELISA
or IHCb 		Path Dx Reference
Braak
Stage		 Diffuse
Plaques		 Neuritic
Plaques		 CAA
DLB Pos. 3 mos. IV Moderate Sparse Severe High DLB, Poss. ADc (Bacskai et al., 2007)
AD Pos. 10 mos. V/VI Frequent Frequent Mild High Def. ADc (Ikonomovic et al., 2008)
CJD Neg. 2 wks n/ad None None None None CJD (Villemagne et al., 2009)
CJD Neg. 4 wks n/a Sparse, frontal only None None Low-None CJD (Villemagne et al., 2009)
Very mild AD Neg. 2.5 yrs III Moderate Sparse Mild High Poss. ADc (Cairns et al., 2009a)
PDD Pos. <15 mos. V/VI Frequent Sparse Moderate High PDD, Poss ADc (Burack et al., 2010)
PDD Pos. <15 mos. V/VI Frequent Sparse Mild High PDD, Poss. ADc (Burack et al., 2010)
PDD Neg. <15 mos. III/IV Sparse None None Few-None PDD (Burack et al., 2010)
A: CDR=0 Neg. 1.7 yrs IV n/a None None Low Normal Brain (Sojkova et al., 2011)
B: CDR=0 Neg. 2.4 yrs III n/a Moderate None Low Poss. ADc (Sojkova et al., 2011)
C: CDR=0 Pos. 2.4 yrs IV n/a Moderate None High Poss. ADc (Sojkova et al., 2011)
D: CDR=0.5 Pos. 1.1 yrs III n/a Moderate Present Low Poss. ADc (Sojkova et al., 2011)
E: CDR=0 Pos. 1.4 yrs IV Frequent Sparse Present High Normal Brain (Sojkova et al., 2011)
F: CDR=2–4.5e Pos. 2 mos. III n/a Moderate Present High Poss. ADc (Sojkova et al., 2011)
1: CDR=0.5f Neg. 36 mos. gHP− n/a 0 n/a 0h n/a (Leinonen et al., 2008)
2: CDR=0f Neg. 23 mos. gHP− n/a 0 n/a 0h n/a (Leinonen et al., 2008)
3: CDR=0f Neg. 15 mos. gHP− n/a 0 n/a 0h n/a (Leinonen et al., 2008)
4: CDR=1f Neg. 2 mos. gHP− n/a 0 n/a 0h n/a (Leinonen et al., 2008)
5: CDR=1f Neg. 5 mos. gHP− n/a 0 n/a 1 (fleecy)h n/a (Leinonen et al., 2008)
6: CDR=1f Neg. 20 mos. gHP− n/a 1 n/a 39h n/a (Leinonen et al., 2008)
7: CDR=1f Pos. 12 mos. gHP− n/a 0 n/a 42h n/a (Leinonen et al., 2008)
8: CDR=0.5f Pos. 26 mos gHP+ n/a 2 n/a 45h n/a (Leinonen et al., 2008)
9; CDR=2f Pos. 27 mos. gHP+ n/a 3 n/a 66h n/a (Leinonen et al., 2008)
10: CDR=1f Pos. 28 mos. gHP+ n/a 0 n/a 80h n/a (Leinonen et al., 2008)
a

Interval between PiB scan and postmortem analysis.

b

Level of Aβ by enzyme-linked immunosorbant assay or anti-Aβ immunohistochemistry (IHC).

c

Possible or Definite AD dementia by CERAD criteria (Mirra et al., 1991).

d

Not assessed

e

Subject F had three assessments.

f

Biopsy study of subjects with suspected NPH

g

Positive or negative for hyperphosphorylated tau (HP)

h

Aβ plaques per ×100 field detected with (IHC)