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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2011 Aug 18;3(1):92–103. doi: 10.1002/wrna.106

Figure 3. Control of HIV transcription by Tat.

Figure 3

1: The binding between Tat and P-TEFb releases P-TEFb from the 7SK snRNP and 2: a Tat•P-TEFb complex is delivered to the promoter proximal paused RNAPII on the HIV LTR through an interaction with TAR, which is present in all nascent viral transcripts. Upon delivery of P-TEFb, the negative factor NELF is phosphorylated and removed. DSIF is also phosphorylated (P) and facilitates the transition of RNAPII into productive elongation.