Table 1.
ARH neuron-specific mutations affecting body weight homeostasis
| Neuron | Mutation | Diet | Food intake | Energy expenditure | Adiposity | Reference(s) |
|---|---|---|---|---|---|---|
| POMC | Lepr KO | SC and HC | – | ▾ | ▴ | (29,57) |
| POMC | SIRT1 KO | HC | – | ▾ | ▴ | (9) |
| POMC | Shp2 KO | SC and HC | – | ▾ | ▴ | (58) |
| POMC | Lepr and IR KO | SC | – | ▾ | ▴ | (66) |
| POMC | Socs3 KO | HC | – | ▴ | ▾ | (59) |
| POMC | PTP1B KO | HC | – | ▴ | ▾ | (58) |
| POMC | 5-HT2CR React | SC and HC | ▾ | – | ▾ | (69) |
| POMC | FoxO1 KO | SC and HC | ▾ | – | ▾ | (70) |
| POMC | IR KO | SC | – | – | – | (57,66) |
| AgRP | Lepr KO | SC | ? | ? | ▴ | (62) |
| AgRP | STAT3 CA | SC and HC | – | ▴ | ▾ | (76) |
| AgRP | IKKβ KO | HC | ▾ | ? | ▾ | (78) |
| AgRP | Vgat KO | SC and HC | – | ▴ | ▾ | (78) |
–, Unchanged; ▴, increased; ▾, decreased; ?, not measured; SC, standard diet; HC, hypercaloric diet; KO, knockout; React, reactivated; CA, constitutively active; STAT3, signal transducer and activator of transcription 3; Vgat, vesicular GABA transporter.