Table 2.
Performance characteristics of multiplex-assayed autoantibody profiles in the diagnosis of rheumatoid arthritis
| Number of positive biomarkers* | PPV | NPV | Sensitivity | Specificity |
|---|---|---|---|---|
| 1+ markers | 79.5% | 92.6% | 96.7% | 62.5% |
| 2+ markers | 91.8% | 89.7% | 93.3% | 87.5% |
| 3+ markers | 95.3% | 79.8% | 84.2% | 93.8% |
| 4+ markers | 95.9% | 61.1% | 59.2% | 96.3% |
*Biomarker panel: histone 2B/e (1-20), vimentin (58-77) (Cit 64, 69, 71), fibrinogenA (616-635) (Cit 621, 627, 630), COMP (453-472), profilaggrin (293-310) (Cit 301, 305), RF-IgA. The cut-off value for positivity was defined as three times the mean value obtained in samples from healthy individuals. PPV, positive predictive value; NPV, negative predictive value.