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. 2011 Nov 16;101(10):2370–2379. doi: 10.1016/j.bpj.2011.10.017

Figure 3.

Figure 3

(A) Probability of transition from the closed to the open state when RyR channel is exposed to [Ca]Cleft for the indicated Δt ms. Circles indicate [Ca]Cleft level if RyR opens for mean open time for each case (black, low SR Ca load;, red, high SR Ca load). (B) Probability that n RyR channels will open when the CaRU is exposed to [Ca]Cleft for 2 ms with a high SR Ca load (800 μM). The orange line indicates the [Ca]Cleft level if RyR opens for the mean open time. (C) Probability that n RyR channels open when the CaRU is exposed to [Ca]Cleft for 1 ms with low SR Ca load (200 μM). The orange line indicates [Ca]Cleft level if RyR opens for the mean open time.