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Pathology following immunization and subsequent lethal challenge in aged Harlan mice. Shown are representative H&E-stained sections of panorama (×100), airway (×400), vasculature (×400), and parenchyma (×400) lung regions from aged mice: (A) mock infected; (B) iFlu plus alum vaccinated, icHC/SZ/61/03-S challenge; (C) DIV plus alum vaccinated, icHC/SZ/61/03-S challenge; (D) DIV plus alum vaccinated, icMA15 challenge. See the legend to Fig. 4 for arrow definitions.
