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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: J Mol Cell Cardiol. 2011 Sep 14;51(6):902–905. doi: 10.1016/j.yjmcc.2011.08.029

Figure 1.

Figure 1

(A) Confocal line-scan images of Ca2+ (expressed as a peak value (F) normalized to minimal fluorescence (F0)) of a representative SANC before and following exposure to 15μM NP-EGTA (small white arrow heads marks LCRs). Histograms of (B) T50 of the AP-induced Ca2+ transient, and (C) the integral of Ca2+ release in the form of LCRs (detected by the Ca2+ indicator). (D) Prior to introduction of the Ca2+ buffer, rhythmic LCR periods were tightly linked to each AP occurrence; but in the presence of NP-EGTA, the LCR periods become dysrhythmic and uncoupled from the AP cycle length. Regression lines are shown with their respective equations.