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. Author manuscript; available in PMC: 2012 Jul 28.
Published in final edited form as: J Med Chem. 2011 Jun 24;54(14):4987–4997. doi: 10.1021/jm2001663

Figure 2.

Figure 2

Collateral sensitivity of MDR cell lines to 1. (a) Dose-response curves of 1 against the P-gp-expressing sub-lines KB-V1, KB-8-5-11 and KB-8-5 and their parental KB-3-1 human adenocarcinoma cell line treated with 1 for 72 h. P-gp expression is KB-V1 > KB-8-5-11 > KB-8-5, and P-gp expression corresponds with toxicity of 1. (b) The MRP1-expressing sub-line MCF-7/VP-16 and its parental line MCF-7. Data are mean ± SD from three independent experiments.