Table 1.
Characteristics of the study population stratified by receipt of nafcillin or cefazolin
| Received only nafcillin or cefazolin (n = 38) |
Received both nafcillin or cefazolin and vancomycin (n = 135) |
Received only vancomycin (n = 94) |
p | |
|---|---|---|---|---|
| Diabetes | 5 (13.2%) | 7 (5.2%) | 13 (14.0%) | 0.06 |
| Renal disease | 0 (0%) | 9 (6.7%) | 13 (14.0%) | 0.02 |
| Severity of illness score, median, IQR | 11.5 (6.0, 16.0) | 16.0 (7.0, 25.0) | 21.0 (14.0, 29.0) | < 0.01 |
| Charlson Comorbidity Index, median, IQR | 0 (0, 2) | 1 (0, 3) | 2 (1,4) | < 0.01 |
| Endocarditis | 9 (23.7%) | 28 (20.7%) | 3 (3.2%) | < 0.01 |
| Pneumonia | 1 (2.6%) | 12 (8.9%) | 3 (3.2%) | 0.13 |
| Osteomyelitis | 1 (2.6%) | 7 (5.2) | 1 (1.1%) | 0.22 |
| Wound Infection | 3 (7.9%) | 4 (3.0%) | 2 (2.1%) | 0.23 |
| Hemodialysis | 0 (0%) | 13 (9.6%) | 18 (19.2%) | < 0.01 |
| Community-associated infection | 26 (68.4%) | 94 (69.6%) | 54 (57.5%) | 0.14 |
| ICU admission before culture collection | 6 (15.8%) | 40 (29.6%) | 28 (29.8%) | 0.20 |
| Age, mean ± SD, year | 51.0 ± 16.4 | 48.0 ± 15.6 | 49.8 ± 16.9 | 0.78 |
| Female sex | 17 (44.7%) | 48 (35.6%) | 32 (34.0%) | 0.49 |
| Presence of central venous catheter | 19 (50.0%) | 61 (45.2%) | 59 (62.8%) | 0.03 |
| Central venous catheter removed | 8/19 (42.1%) | 43/61 (70.5%) | 38/59 (64.4%) | 0.08 |
Data are no. (%) of admissions, unless otherwise indicated. IQR, interquartile range; ICU, intensive care unit; SD, standard deviation.