Table I.
Effect of Dronabinol on Colonic Compliance, Proximal and Distal Left Colon Motility Index, Fasting and Postprandial (PP) Change in Colonic Tone, and sensation ratings in response to distensions
| Placebo | Dronabinol 2.5mg | Dronabinol 5mg | |||||||
|---|---|---|---|---|---|---|---|---|---|
| All IBS | IBS-C | IBS-D/A | All IBS | IBS-C | IBS-D/A | All IBS | IBS-C | IBS-D/A | |
| CYP2C9*3:n with CA/AA genotype | 3/22 | 1/8 | 2/14 | 3/19 | 2/10 | 1/9 | 3/20 | 1/10 | 3/10 |
| Compliance Pr50 (mL/mmHg) | 17.3±0.9 | 16.6±1.4 | 17.6±1.0 | 18.0±1.0 | 18.5±1.1 | 17.4±1.4 | 15.5±1.0 | 17.0±1.3 | 14.2±1.2 |
| Fasting tone, mL | 105.3±4.8 | 98.8±7.3 | 107.1±5.3 | 107.6±5.2 | 110.0±6.0 | 100.3±7.4 | 109.9±5.3 | 107.7±7.1 | 109.1±6.2 |
| PP relative Δ tone (0–30 min) / fasting | 30.0±5.0 | 31.7±7.7 | 27.1±5.6 | 32.8±5.5 | 32.8±6.3 | 32.5±7.8 | 32.0±5.5 | 27.3±7.5 | 35. 9±6.6 |
| Fasting proximal L colon MI | 9.0±0.5 | 8.7±0.8 | 9.3±0.6 | 8.9±0.6 | 8.1±0.6 | 10.0±0.8 | 7.6±0.6 | 7.7±0.8 | 7.7±0.7 |
| Fasting distal L colon MI | 8.0±0.6 | 7.4±0.9 | 8.3±0.6 | 8.3±0.7 | 7.6±0.8 | 8.9±0.9 | 6.8±0.7 | 5.9±0.9 | 7.5±0.8 |
| Mean Pain sensation VAS mm | 42.5±3.5 | 45.8±5.4 | 40.6±3.9 | 42.8±3.9 | 44.8±4.5 | 39.6±5.5 | 46.1±3.9 | 44.1±5.2 | 47.9±4.6 |
| Mean Gas sensation VAS mm | 40.0±3.6 | 42.5±5.6 | 38.5±4.0 | 39.9±4.0 | 41.5±4.6 | 37.3±5.7 | 43.1±4.0 | 41.9±5.4 | 44.0±4.8 |
*
Note there were no homozygous CC participants for CYP2C9rsl057910 in the entire study; data based on total 75 subjects randomized
[ml; least square (LS) means ± SEM]