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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Pain. 2011 Aug 23;152(11):2549–2556. doi: 10.1016/j.pain.2011.07.021

Figure 2. NLB stress produces a prolongation in PGE2 hyperalgesia in skin.

Figure 2

PGE2 (1 μg in 2.5 μl, intradermally) produced a marked decrease in mechanical nociceptive threshold in the hind paw measured 1 h post-injection that returns to near baseline in control (non-stressed) rats (open circles, n=6), when tested 4 h post-injection. In adult NLB rats (filled circles, n=10), PGE2 hyperalgesia was present 1 h post-injection and was still near maximal 4 h post-injection, and still present 24 h post injection. In adult NLB rats, mechanical nociceptive threshold of the skin on the dorsum of the hind paw was not significantly different from the threshold in control rats.