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Ser(P)-129 α-syn dissociation from synaptic membranes. Synaptic membranes isolated from the brains of transgenic mice expressing the human form of WT, A30P, or A53T α-syn were incubated with α-syn−/− cytosol for 10 min at 37 °C. The percentage of membrane-bound and cytosolic α-syn (WT, A30P, and A53T, A–C, respectively) and Ser(P)-129 α-syn (WT, A30P, and A53T, D–F, respectively) relative to starting material are displayed.
