Skip to main content
. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Cancer Discov. 2011 Jul 1;1(2):170–185. doi: 10.1158/2159-8290.CD-11-0039

Figure 2.

Figure 2

Distribution of non-synonymous mutations in A, PIK3CA, B, PIK3R1 and C, PIK3R2. Substitutions (top) and indels (bottom) are graphed with the amino acid indicated and the number of independent observations within parentheses. The percentage of mutations identified in each domain is shown in the box. p110α is characterized by 5 domains: ABD, Ras-binding domain (RBD), C2 domain, helical domain, and kinase catalytic domain. p85 consists of SH3, Rho-GAP, and two SH2 domains (nSH2 and cSH2) that flank an intervening domain (iSH2). *, nonsense mutation; bold, mutations confirmed somatic; red, germline SNPs.