Figure 1.
BAD pathway in genes associated with induced cisplatin-resistance. Thermometers indicate those genes with positive (upward pointing) and negative (downward pointing) correlations between expression and increased cisplatin-resistance (EC50) (P < 0.001 for pathway enrichment): upward pointing thermometers identify genes with increasing expression associated with increasing OVCA cisplatin-resistance, and downward pointing thermometers identify genes with decreasing expression associated with increasing OVCA cisplatin-resistance. Numbers 1–8 at base identify the cell line (1 = T8, 2 = OVCAR5, 3 = OV2008, 4 = IGROV1, 5 = C13, 6 = A2780S, 7 = A2780CP, 8 = A2008) demonstrating changes in expression of that gene with increasing cisplatin-resistance.