Figure 5.
CCL2 nitration/nitrosylation prevents intratumoral T cell infiltration. EG7 tumor samples obtained from either wt or ccr2−/− mice, treated or not with AT38 for 7 d (A) or MCA-203 tumor samples obtained from wt mice that had received intratumoral injections of CCL2 (0.5 µg in hydrogel; B) were stained for CD3 by immunohistochemistry. The graphs represent the quantification of immunoreactive cells (Student’s t test; ***, P < 0.001; n = 20). Bars, 50 µm. Data are representative of three different experiments and are expressed as the means ± SE.