Table 2.
Results of survival analysis of CAPRA-S score, both as a continuous and a categorized variable, illustrating number (N) and % of patients at each score, and the hazard ratio (HR) for progression given with the bootstrap-corrected 95% confidence interval (95%CI) for the HR. Comparisons are given at each CAPRA-S score level relative to CAPRA-S 0 and relative to the prior score (i.e. CAPRA-S 1 vs 0, 2 vs 1, etc.). Actuarial progression-free probability at each score level at 3 and 5 years is given with 95% CI. NS = not significant.
| CAPRA-S | N (%) | Comparison to CAPRA-S 0 | Comparison to prior level | Progression-free probability (95% CI) | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | 3-year | 5-year | ||
| (continuous) | 3787 | 1.54 (1.50–1.59) | <0.001 | ||||
|
| |||||||
| 0 | 1042 (27.2) | ref | 96.3 (94.8 97.4) | 94.5 (92.3 96.1) | |||
| 1 | 826 (21.5) | 1.59 (1.06–2.39) | 0.024 | 1.59 (1.06–2.38) | 0.024 | 95.3 (93.2 96.7) | 91.0 (87.7 93.4) |
| 2 | 669 (17.4) | 3.39 (2.34–4.90) | <0.001 | 2.12 (1.54–2.94) | <0.001 | 89.8 (86.9 92.1) | 83.3 (79.2 86.6) |
|
| |||||||
| 3 | 499 (13.0) | 6.01 (4.18–8.63) | <0.001 | 1.77 (1.35–2.33) | <0.001 | 80.7 (76.5 84.3) | 72.8 (67.5 77.3) |
| 4 | 336 (8.8) | 6.77 (4.57–10.0) | <0.001 | 1.13 (0.84–1.51) | NS | 74.9 (69.3 79.6) | 70.2 (63.9 75.5) |
| 5 | 213 (5.6) | 13.0 (9.01–18.8) | <0.001 | 1.92 (1.43–2.58) | <0.001 | 63.1 (55.5 69.8) | 42.5 (33.4 51.3) |
|
| |||||||
| 6 | 103 (2.7) | 18.9 (12.7–28.0) | <0.001 | 1.45 (1.06–1.98) | 0.023 | 49.2 (38.3 59.2) | 25.9 (16.0 36.9) |
| 7 | 70 (1.8) | 19.5 (12.5–30.5) | <0.001 | 1.03 (0.67–1.59) | NS | 50.9 (37.5 62.8) | 26.9 (15.5 39.7) |
| 8 | 40 (1.0) | 33.4 (20.9–53.5) | <0.001 | 1.71 (1.03–2.82) | 0.026 | 26.9 (12.8 43.2) | 12.3 (2.8 29.4) |
| ≥9 | 39 (1.0) | 64.2 (40.5–101) | <0.001 | 1.92 (1.18–3.12) | 0.01 | 7.3 (1.4 19.9) | 0 |