Table 4.
Uni- and multivariate cox model for overall survival including clinicopathological variables and TLR4 Asp299Gly SNP genotype - hazard ratio point estimates, 95% CIs and p-values (2-sided) from Wald-tests are reported
| Univariate cox model |
Multivariate cox model* |
|||
|---|---|---|---|---|
| hazard ratio [95% CI] | P | hazard ratio [95% CI] |
P | |
| TLR4 Asp299Gly genotype | ||||
| Asp299Asp | 1 | - | 1 | - |
| Asp299Gly | 2.00 [1.02...3.92] | 0.04 | 2.02 [1.01...4.06] | 0.05 |
| Age | ||||
| [per 5 years] | 1.11 [0.98...1.25] | 0.10 | ||
| Sex | ||||
| female | 1 | - | 1 | - |
| male | 2.55 [1.03...6.36] | 0.04 | 2.91 [1.15...7.32] | 0.02 |
| Smoking# | ||||
| no | 1 | - | ||
| yes | 0.91 [0.42...2.00] |
0.82 | ||
| AJCC stage | ||||
| I | 1 | - | 1 | - |
| II | 1.86 [0.70...4.97] | 0.21 | 1.87 [0.70...5.00] | 0.21 |
| III | 2.40 [0.89...6.50] | 0.08 | 2.25 [0.83...6.11] | 0.11 |
| IV§ | 4.08 [1.72...9.66] | 1.1 × 10-3 | 4.66 [1.96...11.09] | 5.0 × 10-4 |
# using 'Mean pack years' instead had no impact on the findings; § which summarizes stages IVA, IVB and IVC