Figure 3.
Elevation of right ventricular (RV) pressure and RV hypertrophy in response to vascular remodeling. (A) RV pressures in control mice and at 4, 8, and 12 weeks (recovery). Control mice (n = 10), 27.0 ± 2.7 mm Hg; 4 weeks (n = 10), 31.6 ± 4.1 mm Hg (P < 0.01); 8 weeks (n = 10), 35.5 ± 7.6 mm Hg (P < 0.05); 4 weeks off treatment (n = 5), 37.0 ± 3.4 mm Hg (P < 0.01). (B) RV to left ventricle (LV) plus septum weight ratio (Fulton index) in control mice and at 4, 8, and 12 weeks (recovery). Control mice (n = 10), 0.18 ± 0.02; 4 weeks (n = 10), 0.2 ± 0.02 (P > 0.05); 8 weeks (n = 10), 0.22 ± 0.03 (P < 0.01); 4 weeks off treatment (n = 5), 0.22 ± 0.01 (P < 0.05). Results are expressed as mean ± SD.