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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Arch Dermatol. 2011 May 16;147(9):1031–1039. doi: 10.1001/archdermatol.2011.119

Table 1.

Six Patients with Psoriasis Demonstrate Whole Body Inflammation Detected by FDG-PET CT

ID Cardiovascular
History		 Psoriasis
History		 Current
psoriasis
treatment
(within 3
months)		 Past psoriasis
treatments
(greater than
3 months
prior)		 Psoriatic
Arthritis		 FDG-PET/CT
Vascular,
SUVmean (SD)		 FDG PET/CT
Liver,
SUVmean (SD)		 FDG-PET/CT Musculoskeletal
Subject 1


41-year-old

Malea 		No CV history

HDL: 36

LDL: 106

BMI: 29.9

hsCRP: 2.9

Medications:

Fish oil		 Duration: 20

years

BSA: 13

PGA: 2

PASI: 7.2

  • NB-UVB (20 treatments)

  • Topical steroids

  • NB-UVB

  • Etanercept

 No AsA 1.84 (0.08)
2.28 (0.36)

  • None
Arch 1.70 (0.06)
TA 1.59 (0.16)
SRAA 1.75 (0.15)
IRAA 1.61 (0.13)
Subject 2


40-year-old

Male		 Hyperlipidemia

HDL: 33

LDL: 161

BMI: 36.7

hsCRP: 2.5

Medications:

Statin		 Duration: 24

years

BSA: 20

PGA: 2.66

PASI: 12.1

  • Methotrexate

  • Abatacept

  • Topical steroids

  • Infliximab

  • Etanercept

  • PUVA

  • Laser



Yes		 AsA 1.67 (0.05) 1.76 (0.19)

  • Inflammation of medial left knee (SUVmax 3.3)

  • Inflammation of posterior left tibiotalar joint

  • Inflammation of muscle and subcutaneous fat within anterior planar aspects of feet and medial plantar aspects of toes

  • Enthesitis of distal right quadriceps tendon (SUVmax 1.7)

  • Sclerosing mesenteritis noted in left mesentery.
Arch 1.53 (0.09)
TA 1.43 (0.14)
SRAA 1.50 (0.07)
IRAA 1.37 (0.13)
Subject 3


56-year-old

Malea 		Hyperlipidemia

HDL: 52

LDL: 90

BMI: 29.1

hsCRP: 0.1

Medications:

Statin, aspirin, fish

oil		 Duration: 8

years

BSA: 19

PGA: 3.3

PASI: 17

  • Topical steroids

  • Topical steroids

 No AsA 1.51 (0.06) 1.64 (0.23)

  • Inflammation lateral to left trochanter (SUVmax 2.2) trochanteric bursitis or enthesitis

  • Enthesitis of right quadriceps tendon (SUVmax 1.7)

  • Synovitis of knee joints bilaterally (right SUVmax 3.0, left SUVmax 2.2)

  • Enthesitis of Achilles tendons (right SUVmax 2.9, left SUVmax 1.8)

  • Inflammation of sinus tarsi bilaterally (right SUVmax 1.5, left SUVmax 2.2)

  • Inflammation of right talonavicular joint (SUVmax 2.0)
Arch 1.40 (0.06)
TA 1.72 (0.10)
SRAA 1.40 (0.07)
IRAA 1.29 (0.15)
Subject 4


53-year-old

Male		 Hyperlipidemia,

hypertension

HDL: 36

LDL: 69

BMI: 35.7

hsCRP: 2.0

Medications:

Statin, diuretic,

aspirin, fish oil		 Duration: 25

years

BSA: 15

PGA: 2.8

PASI: 10.1

  • Topical steroids

  • Topical steroids

  • NB-UVB

 No AsA 1.72 (0.04) 1.56 (0.50)

  • None
Arch 1.62 (0.10)
TA 1.45 (0.16)
SRAA 1.47 (0.05)
IRAA 1.50 (0.14)
Subject 5


58-year-old

Femalea 		No CV history

HDL: 87

LDL:104

BMI: 18.3

hsCRP: n/a

Medications: None		 Duration: 2

years

BSA: 11

PGA: 2

PASI: 9.6

  • Topical steroids

  • Topical steroids

 No AsA 1.52 (0.04) 1.80 (0.14)

  • None
Arch 1.33 (0.08)
TA 1.41 (0.06)
SRAA 1.34 (0.05)
IRAA 1.47 (0.13)
Subject 6


44-year-old

Malea 		No CV history

HDL: 38

LDL: 165

BMI: 24.3

hsCRP: 8.4

Medications: None		 Duration: 3

years

BSA: 10.2

PGA: 2.3

PASI: 6.5

  • Topical steroids

  • Topical steroids

 No AsA 1.40 (0.00) 1.84 (0.26)

  • Focal inflammation of left posterior arm musculature (SUVmax 2.1)

  • Asymmetric inflammation in right knee joint (SUVmax 2.2)
Arch 1.42 (0.42)
TA 1.46 (0.08)
SRAA 1.36 (0.11)
IRAA 1.19 (0.18)
a

Subject is included in the nested case-control study.

b

AsA – Ascending aorta; Arch – Aortic arch; TA – Descending thoracic aorta; SRAA – Suprarenal abdominal aorta; IRAA – Infrarenal abdominal aorta; CV – cardiovascular; NB-UVB – narrow band ultraviolet B therapy; BMI – body mass index; SUV – Standardized Uptake Value.