Fig. 7.
Correlation of C. elegans life span with the overall capacity of the organism to conjugate 4-HNE (panel A) and with the amount of 4-HNE-protein adducts (panel B). The points represent experimental interventions in which the expression of the endogenous gst-10 gene was silenced by RNA interference (gst-10 RNAi), the expression of the same gene was increased by transgenic overexpression (gst-10 tg), or the murine mGsta4 gene was transgenically expressed using the gst-10 promoter (mGsta4 tg). The Pearson correlation coefficients R and the associated P values are given in each panel. Based on data from refs. [110,174,175].
