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Bioaccumulation of PhIP in hair of omnivores and vegetarians. The melanin in the hair follicle has high affinity for PhIP, and sequesters the carcinogen from the blood stream, following first-pass metabolism (24). The LC-ESI/MS/MS trace shows the presence of PhIP in hair of an omnivore but not in the hair sample of a vegetarian. The identity of PhIP was confirmed by its product ion spectrum (607).
