Fig. 2.
hTF N-lobe-TFR interaction motifs (also see Table S1). (A) FeNhTF residues involved in the N1 interaction motif (gray). Arg50, Tyr68, Tyr71, Ala73, and Asn75 within the N1 subdomain of hTF are close to three residues in the helical domain of the TFR (Gly661, Asn662, and Glu664). Residues Leu72 and Pro74, although involved in the N1 interaction motif, have been omitted for clarity. (B) FeNhTF residues involved in the N2 interaction motif (black). The space filling representation of the N2 motif emphasizes that the predominant mode of interaction is van der Waals compared with the H-bonding network for the N1 motif.