Table 2.
Association of Serum Phosphate Concentration with Aortic Valve Sclerosis, Mitral Annular Calcification and Aortic Annular Calcification
| Unadjusted OR (95% CI) | P | Model 1* OR (95% CI) | P | Model 2† OR (95% CI) | P | |
|---|---|---|---|---|---|---|
| Aortic Valve Sclerosis | ||||||
| ≤3.0 mg/dL | 1.0 (Reference) | 1.0 (Reference) | 1.0 (Reference) | |||
| 3.1-3.5 mg/dL | 1.11 (0.82-1.50) | 1.23 (0.91-1.68) | 1.23 (0.90-1.70) | |||
| 3.6-4.0 mg/dL | 1.23 (0.91-1.65) | 1.47 (1.07-2.02) | 1.46 (1.04-2.05) | |||
| >4.0 mg/dL | 1.44 (1.02-2.01) | 1.78 (1.23-2.57) | 1.64 (1.10-2.43) | |||
| per 0.5 mg/dL | 1.12 (1.01-1.23) | 0.03 | 1.20 (1.07-1.33) | 0.001 | 1.17 (1.04-1.31) | 0.01 |
| Mitral Annular Calcification | ||||||
| ≤3.0 mg/dL | 1.0 (Reference) | 1.0 (Reference) | 1.0 (Reference) | |||
| 3.1-3.5 mg/dL | 1.35 (1.00-1.82) | 1.30 (0.95-1.77) | 1.39 (1.01-1.93) | |||
| 3.6-4.0 mg/dL | 1.44 (1.07-1.94) | 1.34 (0.97-1.84) | 1.31 (0.94-1.85) | |||
| >4.0 mg/dL | 1.70 (1.22-2.38) | 1.58 (1.11-2.27) | 1.62 (1.10-2.38) | |||
| per 0.5 mg/dL | 1.16 (1.06-1.30) | 0.001 | 1.13 (1.02-1.26) | 0.02 | 1.12 (1.00-1.26) | 0.05 |
| Aortic Annular Calcification | ||||||
| ≤3.0 mg/dL | 1.0 (Reference) | 1.0 (Reference) | 1.0 (Reference) | |||
| 3.1-3.5 mg/dL | 1.03 (0.77-1.38) | 1.07 (0.79-1.44) | 1.06 (0.77-1.45) | |||
| 3.6-4.0 mg/dL | 1.27 (0.95-1.70) | 1.35 (0.99-1.84) | 1.28 (0.92-1.78) | |||
| >4.0 mg/dL | 1.40 (1.01-1.94) | 1.50 (1.05-2.14) | 1.32 (0.90-1.92) | |||
| per 0.5 mg/dL | 1.14 (1.04-1.25) | 0.006 | 1.17 (1.05-1.29) | 0.003 | 1.12 (0.99-1.25) | 0.05 |
OR, Odds Ratio; CI, Confidence Interval
*
Adjusted for age, sex, and race
†
Adjusted for age, sex, race, estimated glomerular filtration rate, hypertension, diabetes, smoking, body mass index, low density lipoprotein, high density lipoprotein, statin use, vitamin D, parathyroid hormone, calcium, and site