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. Author manuscript; available in PMC: 2011 Jul 22.
Published in final edited form as: Ann N Y Acad Sci. 2009 Aug;1171:59–76. doi: 10.1111/j.1749-6632.2009.04911.x

TABLE 1.

Activators and Inhibitors of Signal Transducer and Activator of Transcription (STAT)-3

Activators Others       • Sodium salicylate64
    Cytokines       • Bile acids34       • Statin65
      • Cardiotrophin-110       • Black soy peptides35       • T4021466
      • CNTF11       • CaMKIIg36       • UCN-0167
      • IFN-γ12       • Diazoxide37       • WP-103468
      • IL-513       • Genistein38     Natural
      • IL-62       • Isoliquiritigenin39       • Caffeic acid49
      • IL-914       • Leptin40       • Capsaicin69
      • IL-1015       • Morphine sulfate41       • CDDO-Me70
      • IL-1116       • Olanzapine42       • Chalcone71
      • IL-1217       • Osmotic shock43       • Cucurbitacin72
      • IL-2118 Inhibitors       • Curcumin73
      • IL-2219     Synthetic       • Deoxytetrangiomycin74
      • IL-2720       • AG 49044       • EGCG75
      • LIGHT21       • Atiprimod45       • Emodin76
      • MCP-122       • Auranofin46       • Flavopiridol77
      • MIP-1α23       • Aurothiomalate47       • Galiellalactone78
      • Oncostatin M24       • BMS-35482548       • Genistein79
      • RANTES23       • CADPE49       • Guggulsterone80
      • SLF25       • Stattic50       • Indirubin81
      • TNF-α26       • Dobesilate51       • Magnolol82
    Growth Factors       • Ethanol52       • Parthenolide83
      • EGF2       • NCX-401653       • Piceatannol84
      • G-CSF27       • Nelfinavir54       • Resveratrol85
      • GM-CSF13       • PDP55       • Silibinin86
      • PDGF4       • Platinum compounds56       • Ursolic acid87
      • TGF-α28       • PS-34157     Others
    Carcinogens       • Y(p)LPQTV58       • EKB56988
      • Diesel exhaust particles29       • R11577759       • GQ-ODN66
      • HCV30       • S31-M200160       • Retinoic acid89
      • LPS31       • S-3I-20161       • Rituximab90
      • Tobacco32       • SCH6633662       • STA-2191
      • UVB33       • SD-102963       • TKS 05079

CaMKII, calmodulin-dependent protein kinase II; CAPDE, caffeic acid phenyl ethyl ester; CDDO-Me, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate; CNTF, ciliary neurotrophic factor; EGCG, (−)-epigallocatechin-3-gallate; EGF, epidermal growth factor; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; GQ-ODN, G-quartet oligodeoxynucleotide; HCV, hepatitis C virus; IFN-γ, interferon gamma; IL, interleukin; LIGHT, lymphotoxin homologue, inducible and competes with HSV glycoprotein D for HveA and is expressed on T lymphocytes; LPS, lipopolysaccharide; MCP-1, monocyte chemoattractant protein 1; MIP-1α, macrophage inflammatory protein-1-α; PDGF, platelet-derived growth factor; PDP, phosphododecapeptides; PS-341, bortezomib; RANTES, regulated on activation normal T cell expressed and presumably secreted; SLF, steel factor; TGF-α, transforming growth factor α; TKS 050, N-{4-[(3,4-dichloro-6-fluoro-phenyl)amino]-quinazoline-6-yl}-2-chloroacetamide; TNF-α, tumor necrosis factor α; UVB, ultraviolet B radiation.