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. Author manuscript; available in PMC: 2011 Jul 19.
Published in final edited form as: Arthritis Rheum. 2010 May;62(5):1361–1371. doi: 10.1002/art.27329

Figure 1.

Figure 1

A and B, Expression of the argonaute (AGO) and DICER1 genes by human osteoarthritis (OA) chondrocytes, as determined by reverse transcription–polymerase chain reaction. Expression of AGO1 was not detected in human OA chondrocytes (A) but was readily detected in human brain mRNA that was used as positive control (B). C, Expression of Dicer-1 protein (217 kd) in human OA chondrocytes. The expression of Dicer-1 was not significantly affected by stimulation with interleukin-1β (IL-1β). D, Cross-species conservation of the microRNA-27b (miR-27b) seed sequence in the 3′-untranslated region (3′-UTR) of matrix metalloproteinase 13 (MMP-13) mRNA. E, TargetScanS-predicted duplex of hsa-miR-27b with the seed sequence in the 3′-UTR of human MMP-13 mRNA.