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Summary. Our results indicate that the Wnt/Ctnnb1 pathway plays a key role in podocyte adhesion, motility, differentiation, and survival. Increased activation of the pathway in DKD might occur to promote podocyte survival, but it also leads to cell detachment and podocyte loss. Down-regulation of the Wnt/Ctnnb1 pathway in podocytes might be important for terminal differentiation; however, it enhances apoptosis susceptibility.
