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. Author manuscript; available in PMC: 2011 Jul 16.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2010 Oct 12;7(11):629–641. doi: 10.1038/nrgastro.2010.154

Figure 5.

Figure 5

Type IV secretion system in the Helicobacter pylori plasticity zone. Gene arrangement in the plasticity region of H. pylori strain Shi470, which has a complete dupA cluster (named tfs3a [type IV secretion 3a]) and functional dupA gene sequence, in comparison with corresponding regions of genome sequences of other H. pylori strains (G27, J99, P12 and 26695). Genes encoding type IV secretion system (T4SS) components are represented by arrows, with frameshift mutations indicated by asterisks. Genes encoding proteins that have 90–95% sequence similarity to the Shi470 proteins are shown in green and genes encoding proteins that have 50–75% sequence similarity are shown in pink. It is possible that only those H. pylori strains that have both a functional dupA gene sequence and a complete tfs3a are pathogenic and have the same action as the cag PAI and ComB T4SS. The numbers shown represent the gene number of each strain deposited in GenBank (GenBank accession numbers for Shi470, G27, J99, P12 and 26695 are CP001072, CP001173, AE001439, CP001217 and AE000511, respectively).