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. Author manuscript; available in PMC: 2011 Jul 16.
Published in final edited form as: Circ Res. 2010 Feb 5;106(2):285–296. doi: 10.1161/CIRCRESAHA.109.209452

Figure 2. Possible mechanisms of S-nitrosylated protein in cardioprotection.

Figure 2

S-nitrosylated proteins could elicit their regulatory effects and protect cells by (A) changing the structure and function of protein due to SNO modification on the active thiol(s); (B) shielding the modified cysteine residues (by S-nitrosylation or S-glutathionylation) from further irreversible modification (indicated as “X”) under oxidative/nitrosative stress; (C) signaling transduction via protein interaction (e.g., GOSPEL/GAPDH).